tonguo
Forum Senior
Topics: 29
Posts: 125
|
hope this can help you and me clarify the concepts in hypersensitivity (it confuses me a lot)
1. a patient with rheumatic fever develops a sore throat from which beta-hemolytic streptococci are cultured. she is started on treatment with penicillin and the sore throat resolved within several days. however, 7 days after start of penicillin therapy she develops fever of 103F, a generalized rash, and proteinuria. the most probable cause is
a. recurrence of RF
b. a different infection
c. an IgE response to penicillin
d. an IgG-IgM response to penicillin
e. a delayed hypersensitivity reaction to penicillin
BTW, what kinds of hypersensitivity can penicillin cause and under what circumstances?
2. the principle difference bw type II and III hypersensitivity is
a. teh class of Ab
b. the site where Ab-Ag complexes are fomed
c. the participation of complement
d. the participation of T cells
|
| mani
Forum Guru
Topics: 104
Posts: 1,403
|
1. its surely a reaction to penicillin, i would go for E
2. b
___________________
Sincerity and hard work are the keys to success!
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
1d
2b
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| tonguo
Forum Senior
Topics: 29
Posts: 125
|
good job! guys, the answer to Q1 is d, and Q2 is b.
so mash, how did u figure out the reaction to penicillin is IgG-IgM reaction, not delayed hypersensitivity? I suppose the reaction here is type III targeting blood vessel wall, do u agree? also, it seems that penicillin can induce type I, II, and III reaction but not IV reaction, any thought on this?
as to q1, the Ag-Ab complex form on cell membrane for type II and on blood vessle wall for type III, right?
any input will be highly appreciated!
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
tonguo, as far as i remember, Pn can ve all types of HSN Rxns
I --- immediate anaphylaxis
II --IgG Abs (warm type hemolytic anemia)
III--- complement mediated(as in this q---causing rash/ nephritis due to immune complex deposition)
IV--too
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| tonguo
Forum Senior
Topics: 29
Posts: 125
|
thank you very much, mash! :icon_salut:
|
| bm
Forum Elite
Topics: 37
Posts: 421
|
hmmm, nice point mash 
|
|
| |
| | | | | | | |
