mash
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can anyone explain cdk family and its function in cell cycle regulation?
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I hear and I forget. I see and I remember. I do and I understand.
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| Ahab
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I see cdks (cyclin dependant kinases) as the protein kinases of cell division. They phosphorylate various regulatory proteins in the cell cycle including Rb (which stops the cycle at g1 before entering s, it is active when hypophosphorlated).
They are activated by cyclins, hence the name and once activated they phosphorylate various enzymes which allow the cell cycle to proceed. I.E. when Rb is phosphorylated it is inhibited and releases the brake on cell division allowing it to enter S. Cyclins are then degraded.
The main cyclins are ABDE, and when placed in order of the cell cycle they go D(g1)E(s)A+B(g2) think Drug Enforcement Agency.
Also it is worth noting that the protein product of the p53 gene, p21 is a cyclin/cdk inhibitor
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| mash
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thanx a lot ahab!
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I hear and I forget. I see and I remember. I do and I understand.
--Confucius
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