daira
Forum Senior
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What is the pathophysiology of development of rash, joint pains, glomerulonephritis? Is it pANCA? How does the rash look like ?
What should be the first step in case of needle pricks from B infected pts? should we check HBsAB only or check the whole profile ? Should we wait for the results or administer Igs anyway?
Which one is associated with preg? is it E?
which one is associated with cryglobinemia? is it C only or both ?
thanks for your time
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| dimps
Forum Guru
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ithink main thing is small vessel vasculitis
as per rash ---
The most common cutaneous lesion is palpable purpura--a slightly raised, non-blanching eruption that usually begins in the lowerextremities.
Occasionally, the rash is vesicular or slightly ulcerated. Urticaria can also be a manifestation of small-vessel vasculitis. Unlike nonvasculitic allergic urticaria, vasculitic urticaria lasts more than one day and may evolve into purpuric lesions.
i think all hepatitis can occur in pregnancy ,it is just that mortality rate is more in case of hepatitis E
ya hep C is ass with cryogloinemia
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| daira
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thanks for your explanation.
Can you explain how is vasculitis caused?
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| Healer4life
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Hi Guys,
This is a HUGE question on the current STEP 2 CK exam and is a key for doing well I think from what I've heard. Please correct me if I'm wrong:
Most allergic Rash or bee-stings, etc. are Type I (immediate IGE mediated hypersensitivity reactions).
Contact Dermatitis (Nickel, jewelery) is Type 4 (T-Cell) hypersensitivity, as is PPD.
RA is a type 2 Hypersensitivity (B-Cell Antibody Mediated) rxn
Osteoarthritis is a non-inflammatory condition so no hypersensitivity, but I don't know the Pathophys for this. Somebody please help.
Someone please help with pathophys for PAN??
Glomerulonephritis: Goodpasteure is Type 2 (antibody mediated with linear immunofluroescence pattern on biopsy), SLE is Type 3 (Immunocomplex (antibody/antigen complexes)) hypersensitivity reaction with "bumpy" immunofluorescence pattern. Post-Strep Glomerulonephritis is also a Type 3 reaction like SLE!!!!
Don't forget that SLE also has a Type 2 hypersensitivity reaction against RBCs causing Warm IgG mediated Extravascular Autoimmune Hemolitic Anemia (AIHA).
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| dimps
Forum Guru
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1 correction qalandar
i just find out that cryoglobulinemia can be caused by many infections
i m writing here complete list
Viral - Hepatitis A, B, and C , HIV, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus
Bacterial - Endocarditis, streptococcal infections, syphilis, Lyme disease, leprosy, Q fever
Fungal - Coccidioidomycosis
Parasitic - Malaria, toxoplasmosis, others
sorry for the mistake
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| daira
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Healer, my understanding of RA is that its type 3. Can you please explain?
What I understand about OA is that its degenerative process, in which bone erosions occur due to cartilage destruction (increased load). This causes a reactive bone formation at the joint margins.
Dimps, thanks for explanation.
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| asmi
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yes RF is type 3 when it involves the kidneys .But when it involves the heart( cytotoxic antibodies)..so type 2 there .
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