mani
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when an APC presents Ag to a CD4 cell with TCR specific for that Ag, CD4 cell becomes active and produces IL-2 which stimulates CD8 and B cells specis for that Ag. Now question is that as the IL2 is nonspecific and can stimulate all CD4. CD8 ANd B cells, why does it activate only Ag specific cells?
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| mdwannabe
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well...IL-2 can a lot of systemic effect..in fact it is suspected to play a role in MODS and SIRS. However, in normal individual IL-2 production is tightly controled. The effects are very. very, very locolized, so the only those T-cells that are in bery close vicinity are activated. In addition there is a genetic component to it. The expression of the IL-2 receptor is controlled in very timely manner.
This is the shortest way to explain this phenomenon.
Hope it helps.
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| mani
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oh yes, receptor thing is quite a good explanation
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| mdwannabe
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Thanks :-)
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