usmle prep
Forum Senior
Topics: 21
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how they differ from each other and which one is the most common cause of hemolytic anaemia??
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| black_tulip
Forum Senior
Topics: 14
Posts: 95
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G6PD is the most common one with Heinz bodies.
PKD is the second most common one without Heinz bodies, but may increase blood lactate and alanine levels.
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| Sakaki-
Forum Senior
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PK deficiency is inherited in an autosomal recessive manner. It is a decrease in ATP generation that leads to chronic hemolysis; the hemolysis may increase in severity during infections.
G6PD deficiency is usually asymptomatic; it is when they are subjected to oxidative stresses (ie. certain therapeutic drugs) or sometimes infections that they develop hemolysis. It is inherited in an X-linked recessive manner.
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| Quinn
Forum Elite
Topics: 63
Posts: 308
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Also, G6PD is self limited because it usually effects only the older RBCs.
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