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shawky2005
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06/26/04 - 12:44 PM       #1

1) what is the difference between albinism and vitiligo ?

2) what is the difference between haemosiderosis and haemochromatosis

3) what is the difference between Karyolysis and Karyorrehxis ?

4) what is the type of necrosis in pneumatocele ?

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bright_nnn
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06/26/04 - 12:54 PM       #2

Karyolysis :arrow: Lysis of nucleus
Karyorhexis :arrow: Fragmentation of nucleus and dissolution

Haemosiderosis :arrow: Accumulation of Fe
Haemochromatosis :arrow: Accumulation of Fe and necrosis of Organs eg Liver

digitaldoc

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06/26/04 - 06:14 PM       #3

1. Albinism is a genetic defect characterised by total absence of melanin pigment - while vitilligo is an acquired disease of possibly autoimmune etiology characterised by patch depigmentation due to destruction of melanocytes

2. hemosiderosis: hemosiderin deposition within cells
hemochromatosis: hemosiderin within cells AND interstitium

3. karyolysis = lysis of nucleus appearing as fading off and disappearance; karyorrhexis = fragmentation of nucleus

4. pneumatocele is a kind of parenchymal necrosis resulting in cyst formation - and i would go with liquefaction ..i cud be wrong

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kalsam
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06/27/04 - 04:55 AM       #4

Even I think Pneumatocele is liquification Necrosis!!!

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shawky2005
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06/27/04 - 08:46 AM       #5

thanks for all and for your good answers especially digitaldoc

Albinism is an inherited disorder of melanin synthesis affecting skin and hair and has two types
a) Tyrosinase -ve .... in which the enzyme is completely absent
b) Tyrosinase +ve ... in which the enzyme is present but there is intracellular inhibition of melanin formation .......

Vitiligo .... is a genetically determined acquired depigmentation of the skin .....

pneumatocele is a liquefaction necrosis as pneumatocele is an example of suppurative infection where pneumococci secrete proteolytic enzymes causing lysis of the parenchymal tissue of the lung ....... and so , the mechanism of necrosis here is heterolysis not autolysis ......

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mani
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06/28/04 - 06:05 AM       #6

an imp difference: in albinism there is failure of melanin production with normal number of melanocytes while vitiligo is loss of melanocytes

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Alena
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07/05/04 - 07:03 AM       #7

Please help me out in getting questions for usmle 1 ( as much as possible), I am on pathology now. If this is not difficult please tell where I can buy Goljan audio + notes. I do need help.
Thank you. smiling face :?: ::very_confused::

mani
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07/05/04 - 03:18 PM       #8

do q book and q bank

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hiwa
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07/05/04 - 03:50 PM       #9

"Alena" wrote:
Please help me out in getting questions for usmle 1 ( as much as possible), I am on pathology now. If this is not difficult please tell where I can buy Goljan audio + notes. I do need help.
Thank you. smiling face :?: ::very_confused::


if u have BSS, pathology part is the same as the audio

mash
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07/05/04 - 04:05 PM       #10

u can download goljan lectures frm www.coolgoose.com...
just follow this post-----
http://www.prep4usmle.com/community/topic9581.html

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Alena
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07/05/04 - 05:57 PM       #11

Hi, Mash,
thanks a lot for the advice,
Alena

Renegade
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07/05/04 - 07:32 PM       #12

Funny, lessons 19 and 28 seem to be missing... 8-[

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