dariush
Forum Elite
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Posts: 356
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2-it increases the HMG-Co reductase inhibition by Statins esp. Lovastatin and Atorvastatin thereby increasing their effects.
it also increases both max. Con. and AUC(bioavailability) but i am not sure it translates into less Vd :icon_scratch:
3- they,though with the same name, are Genetically and clinically two diff. entities,
NF1 --> gene defect on chrom.17(ras inhib.) : Neurofibromatosis+Cafe-au-lait
NF2 -->defect on chrom.22(unkown mech.) : above+ Accoustic Neuroma
both can turn into Malignant Fibrosarcoma.
4- i think "Congenital Melanocytic Melanoma" with Lung Metastasis ::very_confused::
5-they increase the Melanin production as a defence mech. and also Proliferate more,--> more division,and more point mutation --> Melanoma(in the short run) SCC,BCC(in the long run)
..... well too tired cant keep it up, get back here later.
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Allah (God) is watching over us...
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| Sakaki-
Forum Senior
Topics: 1
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7) Prions are not killed by autoclaving.
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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6)Not sure of answer....how about SLE??
8)High CEA indicates Colonic Ca......gene defected can be APC,P53,DCC,k-ras.
9)To increase effectiveness of treatment and also descrease resistance developing from genetic shit in HIV virus???
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| Ahab
Forum Elite
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2- Grapefruit juice inhibits CYP3A4 raising serum conc of these metabolised drugs including some statins (not pravastatin, or fluvastatin)
3. As mentioned above, there is type I and II, two presenting with bilateral acoustic neuromas
4. Liver CA with lung mets?
5. Increased production of melanin
6. SLE
7 Prions (thanks for that one sakaki)
8 P53, k-ras, apc. What gene is overexpressed in colon cancer?
9. HIV has a notorious rate of random mutations rendering single drug resistance rapidly, as of yet I do not think there is any strain resistant to 3 different drugs (god help us if there is, and it becomes as virulent as regular HIV)
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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Thanks Ahab for putting the picture all together!!As for question 4 its unlikely liver Ca and I'm sure its mainly referring to Melanoma....to tell which sort of melanoma we don;t have ample evidence though.
However I would like to hear your point of argument??Are you referring to acanthosis nigricans by any chance??
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| Ahab
Forum Elite
Topics: 9
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I was under the impression that the nevi were referring to spider nevi, cutaneous capillary dilations that appear on the chest wall implying liver dysfunction, hence my guess of liver CA.
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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Ok...naevi are also referred to moles too.....seen in melanomas to suddenly change in size,colour numbers.
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