mani
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whats the cause of hypercalcemia is sarcoidosis?
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| Sakaki-
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There is unregulated synthesis of 1,25(OH)2D3 by activated macrophages in the granulomas.
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| mani
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they have which enzyme? 25-OHLase or 1-OHLase?
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| mash
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macrophages ve 1 hydroxylase
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| mani
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thanx mash
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| mani
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one more point... why hypercalcemia is not seen in every granulomatous disease like TB??
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| mash
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hypercalcemia is seen in other granulomatous disorders -- berylliosis, tuberculosis, leprosy, coccidioidomycosis, and histoplasmosis besides sarcoidosis
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| mani
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oh yes, thats what i thought. thanx mash
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