rubensssss
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The question said:
Which substance made adrenal cortex produce Aldosteron?
A) K
B)Aldosteron
C) Renin
D)ACTH
E) Cortisol
Probable is easy but which ever is your answer I would like to discusse it.
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| rubensssss
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Also I forgot to include:
F) Angiotensin
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| rida
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Well the questions is asking which PRODUCES aldosterone, not release of aldosterone cuz that is by angiotensin, so my guess would be ACTH??
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| rubensssss
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No.
If you have FA 2004,read page 95.
even they give the answer I get it wrong from a test.
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| rida
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well first aid says the regulatory control is renin-angiotensin, i guess its angiotensin??
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| mash
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i think angiotensin bcoz there r just 2 subs dat stimulate release of aldosterone frm the adrenals---AT-II (major)and potassium(direct action on zona glomerulosa)
ACTH has minor transient effect on release of aldosterone
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| Sakaki-
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I agree on angiotensin; it stimulates production when effective circulating blood volume decreases.
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| rubensssss
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NO.
That's why I am confuse. the answer is not letter F.
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| rida
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is it B?? Aldosterone itself??
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| mash
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renin or K?
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| drdk76
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renin- angiotensin is the major control of aldosterone release.ACTH has a minor & transient role.so i think our doubt should narrow down between renin & angiotensin -- it is not mentioned whether it is ang 1 or ang II [ang II in fact stimulates aldosterone secretion]- so i think it's right if we choose renin....
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| suvi21
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Is it K? I rem reading in NJM that plasma K is the strongest stimulator of Aldosterone secretion.
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| rubensssss
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suvi21 yes you are rigth.
That's why I get confused, FA 2004 said it is renin and angitensin.
Answer is letter A
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| rida
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good question ruben!!! I guess thing to remember here is when we have hyperkalemia, aldosterone is activated to get rid of the potassium.
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| rubensssss
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Thanks rida, that's the answer.
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| mdwannabe
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K is the major direct inducer for Aldo...any physio book will say that. Cells in adrenal cortex have special receptors for K...just like cells in thyroid (c-cells) have Ca receptors.
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| mdwannabe
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Please understand it is the DIRECT stimulator... R-A axis is INDIRECT.
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| rubensssss
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K is a direct stimulus of aldosterona synthesis in the adrenal cortex.The plasma K level need increase only 1meq/l to stimulate aldosterona secretion.Elevation in serum K level induce depolarization of the adrenal glomerulosa cells, which activates voltage dependent Ca2 channels and Ca2 influx occurs.
The increase intracellularCa2 concentration facilitated the synthesis of aldoaterona.Reduced renal arterial blood flow and increase in plasma renina and angiotencina I level also stimulate aldosterona synthesis, however they do not act directly on the zona glomerulosa cells.
A decrease in renal arterial blood flow stimulate renin secretion from the juxtlaglomerular cells of the kidney.Renin cleaves angiotensin I from a plasma protein,called angiotensinogen, and angiotensis I is converted into angiotensin II by the angiotensin-converting enzyme.
ANP inhibets aldosterona synthesis.
I know that probable is confused, my questions is which would be the best answer, it is K or aldosteronas?
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