shawn333
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which IL dissloves the bone away , and in which condition it is produced ?
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| mash
Forum Fanatic
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IL1(osteoclast activating factor)
multiple myeloma causing lytic lesions
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| shawn333
Forum Senior
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no mash think again you are wrong.
il 1 is for activation of macrophages ,
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| shawn333
Forum Senior
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il 1 is raised in anemia of chronic disease , think again , mash..wish... we score good .
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| mash
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acc to dr.goljan IL1 is OAF
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| syedaAsma
Forum Newbie
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some say IL 6 ...but its a debate and last time, no one could prove it (on this forum)
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| mash
Forum Fanatic
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IL 1beta and IL 6 form a osteoclast activating complex and is responsible fr lytic lesions in MM...
Interleukin-1–stimulated macrophages lead to the activation of osteoclast precursor cells and result in increased bone resorption(NEJM)
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| Bela
Forum Guru
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Yes guys,
I heard the same thing on dr. goljan's notes. IL1 he said. I read on FA that in MM, IL6 is responsible for the lesions. I'd put IL1 myself if asked.
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| bright_nnn
Forum Senior
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Yeah IL 1Acc.to Dr. Goljan
raised in Osteoporosis and I think in MM too
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| hiwa
Forum Senior
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why estrogen prevent osteoporosis?
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| Gul
Forum Elite
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bcuz it inhibits IL1
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| mani
Forum Guru
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Gul, can u give reference for this??
bcuz it inhibits IL1
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| Gul
Forum Elite
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Goljan
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| mani
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ok thanx
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