shawn333
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sorry rida mash and md wannabe , and every one , i was going into a anxious state and was not feeling myself .
however once again i am back , taking SSRI 
anyway , Why is the FERRITIN RAISED IN THE ANAEMIA OF CHRONIC DISEASE , BUT THE SERUM IRON IS LOW . it is in uppercase ,it is not meant to say that i am shouting .
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Time Wounds all Heals , Contain the damage .
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| shawn333
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what interleukin is inreased in the anaemia of chronic disease .
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Time Wounds all Heals , Contain the damage .
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| syedaAsma
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not sure but anyway IL2?
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| mash
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hey shawn, take it easy....u r gonna do gr8 on the exam ...so, dont take any tensions....
in anemia of chronic ds, Fe is present but is trapped inside the macrophages and is not available fr Hb synthesis
that is why s. Fe is low and ferritin is high (coz storage Fe is high and ferritin levels are directly proportional to storage Fe)
TIBC is low coz high storage Fe signals decreased synthesis of transferrin by the liver
i ll paste a post by sakaki ....he has explained it very nicely
In anemia of chronic disease, there is decreased red cell survival, a blunted response of erythropoietin secretion to anemia, and a block of the transfer of iron from the monocyte-macrophage system (aka. reticuloendothelial system) (all supposedly caused by cytokines). Cytokines such as interferon-gamma are suggested to directly inhibit hematopoiesis as well.
TNF may cause increased sequestration of iron by macrophages, and there is also increased ferritin synthesis (from IL-1) which is not accompanied by a rise in transferrin receptors expression or transcription, leading to a pool of iron not available for hemoglobin synthesis.
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| Sakaki-
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Iron transfer from the storage pool (ferritin and hemosiderin) to the plasma is impaired.
Anemia of chronic disease is more of a result of many different systemic chronic illnesses, but usually, IL-1, IL-6, TNF-alpha and interferon-alpha and beta are increased. The role of IL-6 in ACD is controversial.
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| shawn333
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thank you so much , thanks for great words mash !
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| bright_nnn
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Isnt it that Fe Decreases :arrow: Iron not absorbed properly from GIT
Ferritin Raised:arrow: Released from Liver and Blocked in Macrophages by Cytokines
(ref.:Goljan)
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| Sakaki-
Forum Senior
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The decrease in serum iron per se is not responsible for the decrease in intestinal iron absorption, since the intestine usually increases absorption when the need for serum iron is greater.
Then again, I could just be midunderstanding your post, bright_nnn.
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