rida
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According to kaplan lecture notes, you see increased serum proteins but NORMAL albumin, however, in a kaplan question bank explanation, it said you see DECREASED albumin. Can someone elaborate please??? :?
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| mani
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in my opinion, albumin shouldnt decrease, however i ll welcome any comments for other buddies
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| Idiopathic
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You only have a finite amount of protein...and you will lose protein in the urine, INCLUDING albumin. So, you use up your protein making IgG and have less to make albumin.
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| Sakaki-
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Hypoalbuminemia is an adverse prognostic factor for multiple myeloma.
I suppose albumin would start leaking if there was glomerular damage, which may occur secondary to multiple myeloma.
Isn't the serum protein elevated in multiple myeloma? I don't think that the body has a "finite amount of protein."
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| mani
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i think synthesis of protein is not limited, so if supply of essentials of synthesis is present, it will continue. i think u r reffering to renal loss in myeloma nephrosis, m i rite? yes that can be a cause of low albumin
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| Idiopathic
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"Sakaki-" wrote:
Isn't the serum protein elevated in multiple myeloma? I don't think that the body has a "finite amount of protein."
Remember, visceral protein (albumin, apolipoproteins and IgG) depend on protein intake, whereas muscle can be made from decent carbohydrate intake. I think this is the difference between kwashiorkor and marasmus. The kwashiorkor child gets enough calories, but not enough protein, and so his visceral protein is low. I think (opinion) that this could also happen in hyper-producing states (i.e. multiple myeloma).
However, the answer seems to be nephropathy from Bence-Jones proteins (25% of MM cases).
:lol:
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| rida
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So basically you guys are saying that albumin will be decreased???
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| Idiopathic
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No...just that it can be.
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| mani
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i agree, "it can be". i just tried to clarify the cause for my own sake
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| rida
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Thanx guys!!
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