mani
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whats the mechanism of increased incidence of peptic ulcer in hypercalcemia?
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| Idiopathic
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Usually it is due to MEN I syndrome, which has:
Pancreatic neoplasm - Gastrinoma/Zollinger-Ellison
PTH excess-hyperparathyroidism/adenoma
Pituitary adenoma
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| mani
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thats fine. but i wanna know how hypercalcemia leads to peptic ulcer, read it somewhere but cant recall now
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| Gul
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Hypercalcemia leads to increased gastrin release ....Reference Goljan
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| mani
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i ve read something more specific, dont know how i forgot. could somebody else help me?
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| dranuragagrawal
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gul is right
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| Gul
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Thanks ! for us , i think its adequate , but Mani if u remember the mechanism in detail, do tell!!!
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| mani
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ok i will, if i can recall
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| hiwa
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I think it is the same mechanism as Gul mentioned, because ca attach to calmodulin and stimulate pancreatic enzymes inclusing gastrin to be released
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