docdoc
Forum Senior
Topics: 20
Posts: 104
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Diagnosis is by PE, development of sec. sex. charact. in girls <8yrs or boys <9 yrs.
Management depends on the cause. MCC is idiopathic and Rx is a GnRH analogue. How it works, I dont know.
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| tess
Forum Guru
Topics: 131
Posts: 368
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Neither I can understand why use GnRH agonist for therapy. May be continuous action of the drug (versus pulsatile secretion from the body) have a role here.
GnRH stimulation test is used to confirm the diagnosis. Thanks.
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Yes, GnRH is pulsed in therapy for infertility, but continuous use downregulates endogenous sex hormone synthesis, and shuts down the axis.
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| docdoc
Forum Senior
Topics: 20
Posts: 104
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thanks
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