Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Acetazolamide causes pure loss of bicarbonate and as such, will result in retention of chloride, to maintain the electronegative balance. This is called normal anion gap (hyperchloremic) metabolic acidosis. Chronic acetazolamide use can cause calcium/phosphate loss from bones...this will inevitably be excreted in urine, but that mechanism is indirect, I believe. The main complication is the bone resorption.
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| dariush
Forum Elite
Topics: 20
Posts: 356
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for the same reason good for Hypercalcimia or high amount of any Cations (excep. Li)
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| Ajazzy
Forum Newbie
Topics: 3
Posts: 13
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the retention of CL is thru a na cl co transport and Hco3/ cl- counter transport. The alkalinity of the urine in ACETAZOLIMDE treatment deposits ca phosphate stone and inonizes it there by preventing reabsorbtion of Ca and increased bone loss
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| Sakaki-
Forum Senior
Topics: 1
Posts: 238
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I think that the stones are more a result of increased Ca2+ excretion rather than a cause.
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