bluestar
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due to dilated cardiomyopathy?
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| mani
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dialted cardiomyopathy cant lead to high output. can it?
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| Idiopathic
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Tissues arent picking up oxygen because they dont need it (no acetyl CoA to feed into TCA) and therefore you have increased MVO2...I think this is the problem.
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| Jibbs
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Yeah. The high output failure is as a result of peripheral dilatation of arterioles and capillaries, leading to increased arteriovenous shunting.
So what Idiopathic wrote makes sense.
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| mani
Forum Guru
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in easier words, Thiamine is a cofactor needed for many metabolic enzymes. In its absence tissues are "starved" and tissues "sense" it as a condition requiring more nutrients. so vasodilation results----> increased venous return---->inc cardiac output
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| Jibbs
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Oh, well put, Mani. Welldone.
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