sumeetmultani
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A histological section of the left ventricle of a deceased 28-year-old white male shows classic
contraction band necrosis of the myocardium. Biological specimens confirm the presence of cocaine and
metabolites. Activity of which of the following enzymes was most likely increased in the patient's
myocardial cells shortly prior to his death?
A. Phosphoenolpyruvate carboxykinase
B. Phosphofructokinase-1
C. Pyruvate dehydrogenase
D. Succinate dehydrogenase
E. Transketolase
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| a3112
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B? he will have anaerobic respiration.. so more glycolysis for lactic acid production.. rest all will be decreased..
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| sumeetmultani
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| Passerby
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good question 
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| augmentin
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i couldn`t understand something here....cardiac musle depend on fatty acids in well fed state....and on fatty acid& ketones in fasting state...is there is a role for glycolysis here?!!...and wut about the lactate in the cardiac musle...plz someone explain
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| doc_n_357
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so what's the correct answer?
xould you please post...thanx
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| Orietta
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B is the right answer. This patient w/contraction band necrosis has an hypoxic state in the myocardium, so his ATP come from anearobic glycolysis. In addition cocaine increases NE level which stimulates glycogenolysis (in liver and muscles) and gluconeogenesis (liver). The increase level of lactic acid willl go through gluconeogenesis in the liver and then run through glycolysis to generate ATP.
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| DrLANC
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B is the correct answer. Lets break the question down: 1)Histology shows contraction band necrosis of the myocardium, this is just telling you what they found! 2)There was cocaine and metabolites, Cocaine toxicity or overdose causes excess of NE therefore increased cardiac arrythmias, and increased chance of ischemia, which is what happened here. The patient had a myocardial ischemic attach which caused his death due to cocaine overdose.
If there is ischemia, there is obviously no Oxygen. When there is no Oxygen the cells are forced to undergo Anerobic glycolysis, we have to know what enzymes are involved in Anaerobic glycolysis, so..
Phosphofructokinase-1 is the only enzyme involved in this pathway!!
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