mani
Forum Guru
Topics: 104
Posts: 1,403
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How does methylene THF reductase deficiency causing hyperhomocysteinemia predisposes to thrombosis?
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| Sakaki-
Forum Senior
Topics: 1
Posts: 238
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The elevated homocysteine levels may inhibit the activity of thrombomodulin and lead to platelet dysfunction, with increased levels of thromboxane A2. Moreover, the endothelial cells are damaged, perhaps creating a prothrombotic surface.
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| mash
Forum Fanatic
Topics: 147
Posts: 1,326
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homocystinemia causes endothelial damage, smooth ms proliferation,
upregulation of synthesis of factor VIII and V and downregulation of antithrombotic factors.
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