tess
Forum Guru
Topics: 131
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A 58y man with widely disseminated small cell carcinoma of lung has hypotention, dec serum cortisol levels, and profound eleltrolyte disturbance. What is the cause? What are the changes of serum sodium, potassium, chloride, and bicarbonate?
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| mingle
Forum Senior
Topics: 27
Posts: 109
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adrenal mets with ectopic secretion of adh & acth which occurs in small cells. in squamous it pth
in kidney pth rp
in hepatocarcinomas erythropoietin & insulin like growth factor
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| tess
Forum Guru
Topics: 131
Posts: 368
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Thanks plasmod3. The questions I post are either I have done wrong or I think it is important or difficult to remember. And so all your answers will help.
For this one, it means the disseminated cancer has destroyed most of the adrenal gland so result in cortisol and aldosterone deficiency--- dec serum Na, Cl and bicarbonate and inc K.
GL. 
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| Dot
Forum Senior
Topics: 1
Posts: 168
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i think its praneoplastic syndrome where ectopic tumor produce ACTH and results into electrolyte imbalance but it does not cause cushings.Ref-HARRISON
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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This is most likely mets producing Addisons, rather than ectopic ACTH. Small cell CA is notorious for both (as well as siADH) but mets to the adrenal are very common,
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