mash
Forum Fanatic
Topics: 147
Posts: 1,326
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7.5 gms is toxic dose in adults
kids --- 150mg/kg body wt
age, diet, liver disease, and medical conditions such as fasting, gastroenteritis, chronic alcoholism, or HIV disease affect glutathione stores ===>increased toxicity
Inducers of cytochrome P-450 such as ethanol, isoniazid (INH), rifampin, phenytoin, barbiturates, and carbamazepine can lead to increased production of its toxic metabolite , n acetyl benzoquinoneimene.
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| Swaroop
Forum Junior
Topics: 11
Posts: 37
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just today I saw a case of a 16year old who swallowed 18 tablets of crocin pain relif which each contains 650mg of paracetamol!!!
that means 11700mg!!!= 11.7g
but he survived! I dont know!( 7.5g is toxic dose according to MASH  ) he was in the emergency medical wards....
sorry....I was posted at Dermatology ...so I couldnt enquire much about him 
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