M.A.S
Forum Senior
Topics: 28
Posts: 56
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Hwo much is the toxic dose of acetaminophen in adults?
What are the factors that decrease/increase this toxic dose?
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| tess
Forum Guru
Topics: 131
Posts: 368
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About 7-10 grams (14 to 20 tablets of 500mg each) is toxicity dose; and 12-15 gram (24 to 30 talbets) can be fatal.
Acute alcoholics can dec the severity of intoxicationy; but chronic alcoholics can inc it boz the former inhibit but the latter induce CYP 3A4. I think other drugs having similar effects on CYP 3A4 have similar effects on acetaminophen intoxication. Please correct me if no so.
Hope others add more. thanks.
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