hiwa
Forum Senior
Topics: 15
Posts: 185
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Exercise Is the RIGHT thing to do because
increase temperature
increase co2
decrease PH( lactic formation)
but exercise only for adults( increase 2,3DPG in adult HB) not fetus (low 2,3DPG in fetal HB- shift to the left)
all the above factors shift the curve to the right
shift to the left is mirror image
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| mdwannabe
Forum Guru
Topics: 37
Posts: 1,133
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is that a question.. or statement...???
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| Bela
Forum Guru
Topics: 76
Posts: 412
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I think it's a statement md.
What shifts the curve to the Right is anything that is HIGH, except pH.
1) CO2
2) BPG
3) Temperature as in infection
4) Altitude
5) Hydrogen ions (which translates to low pH)
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| hiwa
Forum Senior
Topics: 15
Posts: 185
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this means any thing associated with exercise shift co2,low PH(high H), temp, adult(rather than fetus) walking up to high place , shift the curve to
the right
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| Bela
Forum Guru
Topics: 76
Posts: 412
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I have a question regarding these two. I know that they shift the curve to the left but was wondering why and don't remember the reasoning behind :?
I mean, I know that they will take up the space for oxygen in the hemoglobin but wouldn't the lack of oxygen in the tissues make the curve to shift to the right in this case since you need the oxygen there?
Or is it simply an affinity curve, meaning how much affinity the Hb has for oxygen?
thnx guys
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| Sakaki-
Forum Senior
Topics: 1
Posts: 238
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Apparently, both methemoglobin and carbon monoxide lead to a conformational change that causes increased affinity for oxygen by the other hemoglobin subunits, thereby shifting the curve to the left.
It sounds counter-intuitive, doesn't it?
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| Rachana
Forum Junior
Topics: 23
Posts: 52
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Here's good mnemonic: CADET
C: CO2 (increase)
A: Acidosis (decrease pH)
D: 23 DPG (increase)
E: Exercise (increase)
t: Temp (increase)
remember everything except pH is increased. Shifts curve to right.
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