Roxanita
Forum Senior
Topics: 16
Posts: 108
|
Q.- In the misincorporation of bases during DNA Replication, Which proofreading activity is critical in determining the accuracy of Nuclear DNA Replication and thus the base substitution mutation rate in human chromosomes?
a) 3' to 5' polymerase activity of DNA Polymerase Delta
b) 3' to 5' Exonuclease activity of DNA Polymerase Gamma
c) 3' to 5' exonuclease activity of DNA Polymerase Delta.
d) Primase activity of DNA Polymerase Alpha
e) 5' to 3' Polymerase activity of DNA Polymerase III
Let's try this one :wink:
___________________
"We all basically have 2 choices in life: Let things stay the way they are or work to make them better"
-Julia Havey
|
| rida
Forum Guru
Topics: 109
Posts: 721
|
C...
___________________
"If He takes you to it, He'll take you through it."
|
| suvi21
Forum Junior
Topics: 6
Posts: 81
|
none of these look correct to me. Shouldn't it be 3' to 5" exonuclease of DNA poly Beta?
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
C) 3' to 5' exonuclease activity of DNA Polymerase Delta.
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| rida
Forum Guru
Topics: 109
Posts: 721
|
Suvi, in prokaryotes, its DNA pol 3, and these are equivalent to Polymerase Delta in the humans (source Kaplan biochem) :o)
___________________
"If He takes you to it, He'll take you through it."
|
| suvi21
Forum Junior
Topics: 6
Posts: 81
|
Kaplan webprep and FA says beta/epsilon involved in repair, delta involved in leading strand poly :roll: !!! confused!!!
|
| suvi21
Forum Junior
Topics: 6
Posts: 81
|
Sorry got it..it says epsilon/beta in repair; that (probably) doesn't mean proofreading
|
| Roxanita
Forum Senior
Topics: 16
Posts: 108
|
Good guys,
Answer: c)
The 3' to 5' Exonuclease activity of DNA polymerase Delta represents the Proofreading activity of an enzyme required for the Replication of Human chromosomal DNA.
DNA Pol Gamma (mitochondrial) & DNA pol III (prokaryotic) do not participate in this process, short RNA primers are replaced with DNA during Replication, and new DNA strands are always synthesized in the 5' to 3' direction.
___________________
"We all basically have 2 choices in life: Let things stay the way they are or work to make them better"
-Julia Havey
|
|
| |
| | | | | | | | |
