intern_doc
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| mash
Forum Fanatic
Topics: 147
Posts: 1,326
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Many drugs require acetylation for their metabolism. Drugs which are significantly metabolised by acetylation include:
isoniazid
hydralazine
procainamide
phenelzine
dapsone
some sulphonamides
there r various genes dat control the expression of acetyl transferases so it exhibits polymorphism.the fast acetylation is autosomal dominant, and the slow is autosomal recessive.The acetylation polymorphism is associated with an increased risk of drug toxicity and some cancers
Fast acetylators (FA) have at least one wild-type allele, resulting in a normal rate of acetylation, while slow acetylators (SA) have two mutant alleles, lowering the acetylation rate.
fr eg . sulphasalazine In fast acetylators, the mean plasma half- life of SP is 10.4 hrs while in slow acetylators it is 14.8 hours....
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| Swaroop
Forum Junior
Topics: 11
Posts: 37
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the main place where the concept of fast and slow acetylation comes into play is in the treatment of TB 
I wanted to write more but mash has written excellent things
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| bluestar
Forum Guru
Topics: 236
Posts: 724
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I never heard about this. please let me know if this is HY? :oops:
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