dariush
Forum Elite
Topics: 20
Posts: 356
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hi there, i wonder if anyone knows why these decrease the Repolarization time. i know they work on Inactive Na channels,but what does it have to do with repolarization ?? :roll:
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| ghizou
Forum Newbie
Topics: 2
Posts: 9
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class1B anti arrythmics decrease action potential duration due to block of the slow NA+ " window" currents
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| dariush
Forum Elite
Topics: 20
Posts: 356
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what do you mean by "window" current, is that the "funny" currents in the SA that generate the AP? if that is so, how would that effect the REPOLARIZATION ?
give me the clue <:help:>
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| ghizou
Forum Newbie
Topics: 2
Posts: 9
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no, it's simple, we have fast na+ channel that lead to depolarization, but at resting mb, we have normal passive na+ leak from extracell to intracell trought slow channel, than if we block this channel, the repolarisation will be faster leading to decrease of action potential duration.
i think it help you to understand.
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| dariush
Forum Elite
Topics: 20
Posts: 356
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thanx, now i got it !
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