intern_doc
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What metals is required in the Collagen synthesis ? :shock:
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| mash
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copper?
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| rida
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copper for enzyme lysyl oxidase.
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| intern_doc
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Darn,
You guys knows your stuff.....
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| rida
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Intern_doc i am glad you asked this question, very high yield, another high yield related to this is which step in collagen synthesis is Vit c necessary for??
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| mash
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hydroxylation of proline and lysine
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| rida
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Yes!
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| Idiopathic
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When type III collagen is laid down in a wound, what enzyme and what cofactor are responsible for converting it to type I collagen (increased tensile strength)?
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| mash
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collagenase
requires Zn
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| Bela
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If copper is lacking, what's the disease? How does it present? What types of collagen does it usually affect?
What organelle/compartment does this step take place in?
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| mash
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Cu is reqd fr assembly of fibrils as a cofactor fr lysyl oxidase
this takes place in EC compt
sorry, dont remember the ds
type III collagen synthesis is defective
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| Bela
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Yes mash, it takes part in Extracellular environment.
Usually lack of Cu is b/c of a XR deficiency in ATP dependent Cu transporter :arrow: Cu is released in feces :arrow: Deficiency of Cu :arrow: Inhibition of lysyl oxidase step :arrow: Menke's Disease
Pt would present with hypopigmentation (of hair, too); aneurysm secondary to arterial tortuosity etc. etc.
What collagen is depleted? I think it's Coll 3 since vessels are involved but I am not sure 
What about Ehlers Danlos? Where does it block collagen synthesis? 
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| mash
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mutation in lysine hydroxylase gene --ED type IX , is AR
mutation in procollagen gene---- ED type IV, AD
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| intern_doc
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if you get deficiency in Cu => Minky Kinky Hair syndrome - hair of pt looks like copper
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| mash
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wow! good way to remember...
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| Bela
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Intern_doc, why though? I mean, u have a lack of Cu....why would the hair look coppry?
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| mash
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bcoz tyrosinase (melanin synthesis)also requires Cu as cofactor
so, cu def leads to steel grey colored hair
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| Bela
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Ok, just looked it up in the google. They said that Cu is lacking in serum and hair :arrow: depigmentation :arrow: very fine and tight strawberry blonde hair
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| Bela
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mash, I thought Cu color is kinda reddish. I mean, English is not my first lang, but it's not steely. :?
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| mash
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bela , tyrosinase converts tyrosine to DOPA :arrow: melanin.
cu is a cofactor fr tyrosinase.
in cu def , melanin synthesis is defective.So, hair is depigmented... this is wat i meant by steel grey color of hair
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