intern_doc
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During which cell cycle does DNA repair occur ?
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| Idiopathic
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G1...the cell cycle is arrested in G1 while p53 scans the DNA for damage. If it can be fixed, it is, if not, then p53 activates the apoptosis gene, bax. All the while, the RB suppressor gene is holding onto the cyclin D/CDK 4 complex. When p53 is phosphorylated, the cell cycle can continue.
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| mash
Forum Fanatic
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dna repair in G1
mismatch repair in G2
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| intern_doc
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excellent....both of you
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| rida
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Where does mismatch of bases occur?
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| mash
Forum Fanatic
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mismatched bases r missed by proofreading function of DNA polymerase during S phase
these r recognized by proteins ka hMLH & hMSH which remove these bases in G2 phase
HNPCC is one condition where these mismatched bases r not repaired
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I hear and I forget. I see and I remember. I do and I understand.
--Confucius
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| rida
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Excellent, i can see you know your kaplan notes really well :o)
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