mjl1717
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there is a maturation defect in the DNA synthesis so the MCV is greater then 100
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| intern_doc
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Darn,
You guys are too deep. BTW, is that important ?
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| mjl1717
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folate vs B12 is important
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| intern_doc
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Oh I know folate and b12 is important...now doubt....but i was refering to idagr811 question
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| mingle
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if you look at all the haematopoiesis processes the cells always start out big & then become smaller & smaller as they become more & more mature. in b12 & folate deficiency there is a block to their maturation as they cannot do proper dna hence they are bigger. hmmm hope thats right ))))
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| Sakaki-
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I like to associate the term nuclear:cytoplasmic asychrony with B12/folate deficiency since the nucleus and cytoplasmic stages in the BM do not match.
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| Quinn
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That is what I was thinking Sakaki. Which is correct.....asychrony or no maturation?
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| Sakaki-
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I think that the nucleus does continue to mature to a certain extent; there is not only one stage of nucleus maturation in the BM. However, it lags behind relative to the degree of maturity of the cytoplasm. For example, there are promyelocytes and giant metamyelocytes (with different chromatin patterns).
Maturation arrest is a feature of severe megaloblastosis.
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| Quinn
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Thanks Sakaki !
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