tess
Forum Guru
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There is polyglandular deficiency syndrome type I and II, what is the difference between the two? Thanks.
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| doc4mindia
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:!: Type 1 is also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APCED) syndrome and is caused by a defect in T cell-mediated immunity inherited as an autosomal recessive trait.
It usually presents in early childhood with mucocutaneous candidiasis, followed by hypoparathyroidism and dystrophy of the teeth and nails; Addison's disease usually appears by age 15 years.
Partial or late expression of the disease is common.A varied spectrum of associated diseases may be seen in adulthood,including hypogonadism, hypothyroidism, pernicious anemia, alopecia, vitiligo, hepatitis, malabsorption, and sjogren's syndrome.
:!: Type 2 PGA usually presents in adulthood with autoimmune adrenal insufficiency that is HLA related.;;no hypoparathyroidism.
It is associated with autoimmune thyroid disease, vitiligo, type 1 diabete, alopecia areata, or celiac sprue.
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| xmihaela
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A good explanation. Thanks
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| tess
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That was a good one.
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