suvi21
Forum Junior
Topics: 6
Posts: 81
|
Which of the following laboratory patterns is most consistent with the diagnosis of hemochromatosis?
Answer Choices
A. Increased iron, increased TIBC (total iron-binding capacity), and increased ferritin
B. Low iron, low TIBC, and low ferritin
C. Low iron, low TIBC, and increased ferritin
D. Low iron, increased TIBC, and decreased ferritin
E. Increased iron, normal TIBC, and low ferritin
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
in hemochromatosis S. Fe is increased
TIBC is decreased
S ferritin is increased
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| suvi21
Forum Junior
Topics: 6
Posts: 81
|
I agree, so does any of those answers look correct to you? The ans says A!!
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
coz in fe overload, transferrin synthesis by liver is decreased
so, TIBC will decrease
none of the choices seems correct to me :icon_scratch:
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
The question could have meant to put %sat instead of TIBC...that is the only way A could be right, but none of the others are right either.
|
| intern_doc
Forum Guru
Topics: 98
Posts: 433
|
It should be
increase serum iron
decrease TIBC
increase ferritin
but it's NOT as one of the choice here. Either it's a typo or the question is wrong
___________________
Please call me by my first name on March 17 - Dr.
|
| suvi21
Forum Junior
Topics: 6
Posts: 81
|
Thanks for all those who attempted, its not a typo, I got it in Q bank, felt the Q was wrong, so posted it, just to make sure everyone feels so.
|
| mingle
Forum Senior
Topics: 27
Posts: 109
|
hi mash why is transferrin synthesis decreased in haemachromatosis?
|
| mash
Forum Fanatic
Topics: 147
Posts: 1,326
|
Cellular iron uptake and storage are coordinately regulated through a feedback control mechanism mediated at the post-transcriptional level by cytoplasmic factors know as iron-regulatory proteins 1 and 2. These proteins "sense" levels of iron in the transit pool and, when iron in this pool is scarce, they bind to stem-loop structures known as iron-responsive elements on the 5' untranslated region of the ferritin mRNA and 3' untranslated region of the transferrin mRNA. Such a binding inhibits translation of ferritin mRNA and stabilizes the mRNA for transferrin . The opposite scenario develops when iron in the transit pool is plentiful. This remarkable regulatory mechanism prevents the expansion of a catalytically active intracellular iron pool, while maintaining sufficient concentrations of the metal for metabolic needs.
___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius
|
| mingle
Forum Senior
Topics: 27
Posts: 109
|
woww thanks mash
|
|
| |
| | | | | | | | | | |
Similar forum topics