mjl1717
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What is the most common cause of an elevated homocysteine level in the U.S.?
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| mash
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B12/ B6/ folate def , all 3 can lead to homocystinemia
Though im not sure but i think folate def is the most common cause in US :?
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| Idiopathic
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It is more likely to be folate deficient, that is for sure.
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| dxtxpx
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The accumulation of homocysteine and its metabolites is caused by disruption of any of the 3 interrelated pathways of methionine metabolism—(1) deficiency in the cystathionine B-synthase (CBS) enzyme, (2) defective methylcobalamin synthesis, or (3) abnormality in methylene tetrahydrofolate reductase (MTHFR)
Out of these CBS synthase is more common
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| mjl1717
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Folate def. is correct
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| dxtxpx
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can u please tell the source, if its not a trouble. thanks
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| suvi21
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most common cause of an elevated homocysteine level in the U.S. is folate def, secondary to alcoholism
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| mjl1717
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No dx, its not too much trouble-Source -Dr Goljan.
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| dxtxpx
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thanks  i have goljan stuff, just havent gotten around to it yet
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| SilatK
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Could this be in the Step 1 Rapid review series by Goljan?
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