piter
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A 54-yo man presents with productive couth and weight loss over the past 8 months. Chest x-ray reveals a large hilarvmass, and sprutum cytology shows cells with hyperchromatic nuclei, little cytoplasm. and inconspicuous nucleoli. This malignant cells most likely originated from a
A. clara cell
B. metaplastic bronchial apitelial cell
C. neuroendocrine cell
D. type I alveolar pneumocyte
E. type II alveolar pneumocyte
and name the cancer
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| peekay
Forum Guru
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IS IT CLARA CELL DUE TO SQUAMOUS CELL CA.
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| shawn333
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function of clara cells is p450 oxidation
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| piter
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no, it's not clara cells
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| mash
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c) neuroendocrine cells in small cell ca
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| piter
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correct mash!
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| mdwannabe
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Ok lets list major path features for most popular Ca's of the lung. I know you guys know...but lets just recap.
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| mash
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squamous cell ca ------ asso with smoking
main bronchus
sq metaplasia----> dysplasia------> in situ-----> invasive ca
M/E keratin pearls
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| mjl1717
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1) smoking most associated with small cell and squamous
2) MC cause of cancer death!!/second most common CA
3) 35% are adenocarcinoma (more peripherally)
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| piter
Forum Elite
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also
squamos cell carcinoma - PTH activity
small cell carcinoma - ADH, ACTH activity
superior vena cava sydrome
pancoast tumor with horner sydrome
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| mjl1717
Forum Hero
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also
squamous is 30%- located centrally
metastasis to the lung is the most common lung CA (breast CA is leading cause.
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| peekay
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thanks every one for clarification
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