M.A.S
Forum Senior
Topics: 28
Posts: 56
|
As I know, if ECF volume decreased then acidosis tends to occur; if ECFV increased there will be an alkalosis.
There are special cases (such as: nausea ---> HCl loss and decreased ECF ---> metabolic alkalosis)
But now I have read a different things about renal acid-base control:
In general:
decreased ECFV ---> increased tubular reabsorption of Na ---> increased Na+/H+ exchange ---> increased HCO3- reabsorption ---> METABOLIC ALKALOSIS
increased ECFV ---> decreased tubular reabsorption of Na ---> decreased Na+/H+ exchange ---> dencreased HCO3- reabsorption ---> METABOLIC ACIDOSIS
Which is correct?
|
| Idiopathic
Forum Guru
Topics: 19
Posts: 641
|
decreased ECFV (or EABV) leads to increased secretion of aldosterone, which results in a metabolic alkalosis (due to exchanging H+ for K+ in the distal tubule). Conn's syndrome (primary aldosteronism) is, in fact, noted for causing a metabolic alkalosis.
increased ECFV will give the opposite picture, as it will suppress aldosterone release.
|
| mani
Forum Guru
Topics: 104
Posts: 1,403
|
MAS would u cladify what exactly is ur confusion?
___________________
Sincerity and hard work are the keys to success!
|
| M.A.S
Forum Senior
Topics: 28
Posts: 56
|
Thank you all, the wrong thought is to consider ECFV as the only factor affecting acid-base balance, rather than the type of lost fluid (gastric acid loss in nausea, or loss of base like in diarrhea), so other factors and electrolytes should not be ignored. Thank you together Idiopathic and Salman.
|
| Sakaki-
Forum Senior
Topics: 1
Posts: 238
|
A decrease in ECF volume per se is more of a factor that perpetuates metabolic alkalosis or maintains such a state rather than serving as a primary cause usually.
|
|
| |
| | | | | |
Similar forum topics