dxtxpx
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What does anaplerotic means in Krebs cycle?
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| santaclara
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Reactions that replenish TCA cycle intermediates and allow respiration to continue.
correct me if wrong. :roll:
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| whereami
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I agree with santaclara. I vaguely remember it as the conversion of amino acids or fatty acids (?) to Kreb cycle intermediates.
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| dxtxpx
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correct
Enzymatic steps that are used to contribute intermediates in Krebs cycle are termed anaplerotic and include:
Pyruvate carboxylase [catalyzes pyruvate :arrow: Oxaloacetate step]
Glutamate dehydrogenase [catalyzes glutamate :arrow: alphaketo-glutarate step with production of NADH and ammonia]
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| santaclara
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hello dxtxpx.
i understand your reply but can u tell me one more thing from which cycle they come and contribute for kreb.
i also write the answer that they allow respiration.
i don't understand this as well. :roll:
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| dxtxpx
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This step is from gluconeogensis in mitochondria: Pyruvate carboxylase [catalyzes pyruvate :arrow: Oxaloacetate step]
This step is from nitrogen metabolism in liver: Glutamate dehydrogenase [catalyzes glutamate :arrow: alphaketo-glutarate step with production of NADH and ammonia]
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| santaclara
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thanx.
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