almina
Forum Senior
Topics: 34
Posts: 99
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The most important e/cel urinary buffer is:
A. ATP
B. proteins
C. HCO3
D. H2PO4
The pk of CO2/HCO3- buffer pair is 6,1. What are the relative concentration of CO2 and HCO3- in blood sample that has pH of 7,1? Please explain.
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| Sakaki-
Forum Senior
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Posts: 238
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H2PO4 is the most important urinary buffer. It has a favourable pKa.
By the Henderson-Hasselbalch equation, pH = pKa + log [HCO3-]/[CO2]. Therefore, 10^(7.1-6.1) = [HCO3-]/[CO2], and so the ratio is 10, with ten times more HCO3- than CO2.
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| GS
Forum Newbie
Topics: 7
Posts: 22
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I beg to differ .The normal ph of urine is 4.6 to 8 with a av of 6.0 .the pk of bicarbonate buffer is 6.1 and that of phosphate is 6.8 so bicarbonate is more imp
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| dranuragagrawal
Forum Newbie
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po4 is the 1st to be used contributes to 33 % of neutralization.and is titrable
its more important.only after po4 is used up that hco3 is used
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| Sakaki-
Forum Senior
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Posts: 238
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Isn't bicarbonate the first one to be used up since its pKa is the closest? On the other hand, I believe that the phosphate buffer is the most important since it predominates in a quantitative sense (as the bulk of HCO3- is reabsorbed anyways in the PCT).
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| mani
Forum Guru
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quantitatively most imp is phosphate buffer, then is ammonia buffer.
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| mdwannabe
Forum Guru
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i agree, the most important is PO buffer, just coz the amount of Phospate lingering around in body.
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| dranuragagrawal
Forum Newbie
Topics: 2
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i might have got it twisted :?:
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| DiaHuq
Forum Elite
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the most important urinary buffer is the phosphate buffer.CO2/HCO3 buffer is more important blood buffer
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| rubyduby
Forum Newbie
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thanx huq! u made difernece b/t urinary and blood buffers its clear now on
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