sing
Forum Guru
Topics: 153
Posts: 370
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Dear all, I posted this question previously and got two answers.
Ans1: Eosinophilic granuloma in Histocytosis X
Ans2: They are seen in langerhans cells of the skin, which are also tennis racket shaped cells. Are antigen presenting cells.
Are those two answers agree with each other? Which is correct? Thanks.
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| mash
Forum Fanatic
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Posts: 1,326
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BIRBECK GRANULES - Tennis racket shaped structures found in Langerhan's cells in histiocytosis X (Langerhan's cell histiocytosis) which includes eosinophilic granuloma, Letterer-Siwe disease and Hand-Schuller-Christian disease.
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| sing
Forum Guru
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thanks, mash.
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| Quinn
Forum Elite
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Well said mash!!
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| nilslam
Forum Newbie
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High, I'studying for the Path Boards, and I can tell you that Birbeck granules are found in both normal Langerhans cells of the skin and more importantly in Histiocytosis X (Langerhans Histiocytosis, eosinophilic granuloma). It is used to differentiate this histiocytosis from other histiocytoses like Erdheim-Chester disease and Rosai-Dorfman disease. The Birbeck granule has a Tennis Racket shape, if you see the whole thing, but often, only the tubular structure (the handle of the racket) shows up. So watch out. Histiocytosis X is a young Kids disease, whith most cases occuring up to the age of 15. Often the first presenting site is the Lung, it's called here eosinophilic granuloma. The systemic form (Letter-Siwe disease) occurs usually in the first year of life and presents in many organs and the skin.
I hope this helps. :lol:
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