jessie1976318
Forum Junior
Topics: 24
Posts: 42
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1 one kid got vaccine, but the antibody function is abnormal. it can induce ADCC( complement mediated), but not macrophage mediated lysis.answers I can remember is
a the light chain of Ab dysfunction b heavy chain dysfunction c dysfunction of maturation of ab, isotope shift .......
2 fever 4 days after operation. blood cuture get Staphylococcus aureus . where is the origin of infection. answers I can remember:
would ,stool, sptum...
3 how does AMP increase the gluycolysis ?
4 the patient has neoplasia in pancreas, which secrete much gastrin. which drug should be used before the surgery?
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| Malaysian
Forum Guru
Topics: 28
Posts: 778
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Thanx jessie.What answers did u give for these questions??
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| maalaaak2000
Forum Junior
Topics: 13
Posts: 26
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Hi there and this is my answers:
1. Chronic granulomatous disease.
2.wound infection.
3.?
4.H2 blocker.
I hope I am right...................
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| bluestar
Forum Guru
Topics: 236
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for Q1, why is it CGD? the question says Ab abnormal?
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| mingle
Forum Senior
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the first answer is ig class switching & the last q is octreotide(synthetic somatostatin )))
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| ardeophyte
Forum Newbie
Topics: 1
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For #3,
AMP and fructose 2,6 bisphosphate stimulate the enzyme phosphofructokinase-1 (PFK-1), while citrate and ATP inhibit it. PFK-1 catalyzes an irreversible step in glycolysis.
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| humbty
Forum Elite
Topics: 24
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The Makrophage has a Fc Receptor, if phagocytosis doesnt work i would say its a dysfunction of the heavy chain. :idea:
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| Salman23
Forum Senior
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HI jessie,
I would say that its not very wise to post your exam questions on a forum...U might get into trouble, last year, 7 people got barred just because of the same reason....
Dont mean to sound discouraging, but 5-6 questions isnt worth the risk
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| nuprin
Forum Elite
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i think these are from nbme form 1
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| retroviridae
Forum Guru
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I've seen these before too. Must be from NBME form I
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| bluestar
Forum Guru
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"plasmod3" wrote:the first answer is ig class switching & the last q is octreotide(synthetic somatostatin ))) if only the abnormality is class switching then why ADCC is normal in this patient? As I remember, there are two forms of ADCC, one is IgG-Macrophage mediated viral infected cell lysis , the other is IgE-eosinophil mediated helmith toxicity. So if ADCC is normal then at least the patient can produce IgG and IgE.
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| mingle
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it's this way see. igm & igg both can activate complement by the classical pathway. iga & ige by the alternative pathway but only igg can opsonize. opsonizing is the process involving the macrophage whereas complement mediated adcc can be done by both igm & igg.
now we know that ag class switing needs a few factors like il4 for ige & il5 for iga also it needs cd40 & cd40l interactrions as well as functioning thyrosine kinases activated by the 40-40l interaction. so if the ab starts as igm then igg then ige and finally iga, if it could not ab switch to igg then there is no possible opsonization by antibodies. this guy very simply in one word is likely to have hyper igm disease...thats the disease where the cd40l on the t cell can'[t do crap)))))
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| bluestar
Forum Guru
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"plasmod3" wrote:
.. but only igg can opsonize. opsonizing is the process involving the macrophage whereas complement mediated adcc can be done by both igm & igg. please kindly tell me how IgM is involved in ADCC. As I know, only IgG and IgE are involved in ADCC because macrophage or NK cell has IgG heavy chain receptor and eosinophil has IgE heavy chain receptor
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| ddd
Forum Newbie
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Adcc can be of two types
complement mediated-IgM and IgG both can activate the complement and cause lysis. IgM is more effective
NK or Macrophage mediated-ONLY IgG has the Fc receptor and causes phagocytosis
Inthis patient- Normal complement mediated lysis but abnormal phgocytosis combined with low immunoglobin levels indicates LOW IgG. Hence answer is abnormal isotype switching, low IgG.
Just for extra info, in this patient
When no precipitation it indicates- antigen excess(low IgG)
passive Hemeagglitination positive- indicates normal IgM levels
Please do correct me if I am wrong anywhere. it took me few minutes to really understand the basics:-(
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