mash
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wat wud be the primary acid base disturbance in a person who has just arrived at a high altitude?
kaplan physio page365 fig VIII-1-2 (I)
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| rida
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Respiratory alkalosis due to hyperventilation.
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| mash
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thanx!
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| mani
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most primary disturbance would be metabolic acidosis due to hypoxia. This will be corrected by hyperventilation leading to metabolic alkalosis. As a compensation kidney will excrete bicarbonate thus returning pH towards normal.
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| rida
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Mani are you referring to high altitude as in primary disturbance metabolic acidosis???
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| mani
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no its just theoretical. The sequence will be as i have listed but the obeserved finding will be metabolic alkalosis, ,as resp compensation is very rapid. So although 1st disturbance will be metabolic acidosis but obeserved will be metabolic alkalosis.
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| mash
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i think primary disturbance wud be respiratory alkalosis (due to hyperventilation)
mech of hyperventilation ------- low systemic arterial PO2 will stimulate peripheral chemoreceptors.
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| Sakaki-
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Hmm--how would hypoxia result in metabolic acidosis? Oxygen per se exerts no acid-base effect. I too believe that the primary disturbance would be due to hyperventilation (which decreases the PCO2 and results in respiratory alkalosis).
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| mani
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ok i agree
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