carina
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Topics: 92
Posts: 191
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20. A 63-year-old male with chronic rheumatoid arthritis
presents with proteinuria and the nephrotic syndrome. A
rectal biopsy is performed, which demonstrates amyloid
deposition. Amyloid deposition in this setting
Is within the cytoplasm
Contains mainly (>50%) P component
Is derived from an acute-phase reactant (SAA)
Does not show birefringence after Congo red stain-
ing
Is derived from lambda light chains
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| Karime
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Does not show birefringence after Congo red staining????
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| kleovoulos
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Amyloid protein in the setting of a chronic inflammatory disease as RA is formed by Serum amyloid associated protein ( SAA) and it is called "AA protein", whereas amyloid formed in the setting of immunocytic dyscrasias e.g multiple myeloma consists of immunoglobulin light chains, the so-called "AL protein".
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| kleovoulos
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so, the answer is (C)
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| brainstem
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C - Secondary amyloidosis - RA, SLE, TB, OSTEOMYELITIS, CROHNS, CANCER etc.
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