alirizvi
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I forget the pathophysiology behind increase blood pressure on standing and decrease in supine. I know the one scenario with SVC obstruction but can someone explain me the scenario dealing with adrenal or kidneys.
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i can't remember the exact sequence of it, but something along the lines that there's a sympathetic release to counteract the effect of gravity........
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btw, are you asking about normal physio. or pathophysio. in disease state and how the BP will be maintained then?
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| alirizvi
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it was pathophysio, sry for the confusion. But i just found out what i was looking for.
When u go to supine you have increase blood to heart and increase pressure on L.A and release ANP and decrease BP. But then when u stand you have increase flow to adrenal and if u have a aldosterone secreting tumor you will release more of the hormone into the blood and increase the blood pressure. I dont know if this tumor works only with Conns disease or cushing or both ( if u can clarify that, then thnx in advance )
The interesting thing i also found is the lab.. You will have normal Na+ since u have naturesis due to ANP and iincrease absorption due to aldosterone. and as always renin and other stuff will be low.
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| alirizvi
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oh and i guess this is why u dnt have edema with Primary aldosterone increase ( due to Na+ escape ) . But with 2ndary aldosterone u do.
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 wow.......good to know.
well, gl with your exam.
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alirizvi wrote:
I dont know if this tumor works only with Conns disease or cushing or both ( if u can clarify that, then thnx in advance )
yeah i'll search it, i'll let you know what i find.
(or if you get to it before me, let me know!)
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| alirizvi
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by the way,they had this on house, because this lady came in and she would stand up and her bp will increase due to the tumor and reflex drop in heart rate.. and then house was so confused  .. at that time, if sum1 asked me what is an adrenal GLAND ? i would have said something in the mouth 
i think it might be both.. just know one is hypertrophy and one is hyperplasia. The rest the labs are same.
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