keepgoing
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Chloroquine is a weak base that neutralizes acidic organelles. In a pancreatic beta cell, which of the following would be a direct effect of chloroquine treatment?
a. Increased proinsulin content in secretory vesicles
b. Increased release of C peptide
c. Increased number of amylase-containing secretory vesicles
d. Reduced translation of glucagon mRNA
e. Increased stability of insulin mRNA
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| kingsof2005
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wow crazy question.....A?
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| keepgoing
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yeah indeed it is,i didnt know this,
what is MOA of it and uses.
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| kingsof2005
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keepgoing wrote:
yeah indeed it is,i didnt know this,
what is MOA of it and uses.
uses---malaria...maybe in sle and other autoimmune disorders
moa----enters rbc....degrades heme...uses the aa from it to construct its own protein
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| keepgoing
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Alkalinization of food vacuole: Chloroquine is taken up into the parasite's food vacuole by an active transport system. Inside the acidic vacuole the drug, which is very basic, com-
bines with a proton and is trapped, resulting in alkalinization of this organelle. This causes an inability of the parasite to carry out hemoglobin digestion.
Decreased DNA synthesis: The drug can also decrease DNA synthesis in the parasite by disrupting the tertiary structure of the nucleic acid.
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| keepgoing
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Chloroquine neutralizes acidic compartments such as the secretory vesicles. Chloroquine treatment inhibits the conversion of proinsulin to insulin, resulting in decreased formation
of insulin within secretory vesicles.
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| kingsof2005
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excellent ques thanks
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| keepgoing
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this means chloroquine when given in malaria patient wud thisaffect insulin secretion too 
now what are s/e of chloroquine?
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| kingsof2005
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yes
se-----mostly minor.....gi,headache....possibly mood swings or retinopathy
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| keepgoing
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yes right.GI upset,skin allergy and headache,visual disturbances.
The inhibition of gluconeogenesis by chloroquine contributes to its hypoglycaemic action. Chloroquine-induced changes in levels of intracellular gluconeogenic intermediates indicate a decrease in phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities probably due to increased concentration of 2-oxoglutarate, an inhibitor of these two enzymes. In view of the data, it is likely that inhibition by chloroquine of glucose formation in liver and kidney may contribute to the hypoglycaemic action of this drug.
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| kingsof2005
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wow 2 oxoglutarate neva heard of that b4 lol
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| keepgoing
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 same here i just searched to find out if we do see hypoglycemia and found its diferent story,lol not bcoz less insulin seretion,anyways now makes some sense anyways good review thanks kingsof2005.
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| kingsof2005
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np thx for sharing
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| keepgoing
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u r welcome,thanks for showing interest.
oh forgot one more aspect.
what are contraindications for thsi drug any idea?
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| new_n_lost
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Corneal and Retinal deposition resulting in loss in sensations and visual acuity respectively. Bulls eye Maculopathy is the end result in toxicity
Systemic mansifestations would be like pruritis and palsies Me thinks
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