ngaybinhyen wrote:
1. Salicylate poisoning
- recommended in all symptomatic patients with regard of hypokalemia (common in salicylate poisoning)
- Diamox should NEVER be used as for acidemia and subsequent increased toxicity
2. Urinary alkalinization by PO NaHCO3 enhances the elimination of weak acids: salicylates, phenobarbital, chlorpropamide, chlorophenoxy herbicides, formic acid, and methotrexate
3. Pure uric acid stones
- dissolved with oral alkalinization, K citrate, Na bicarbonate --> urinary pH 6.5-7
4. Rhabdomyolysis: IV bicarb
5. hemoglobinuria (heatstroke)
 !
A little of mechanisms:
1 and 2. Increase polarity of substance and its excretion.
2. decreases precipitation
3 and 5. decreases protein denaturation
What conditions are treated with urine acidification?
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| docnit
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| GOGETA
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What conditions are treated with urine acidification?
proteus infection and struvita calculo
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| ngaybinhyen
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actually, urine acidification is not recommended any more as it harms more than it benefits the patients. Correct?
Keep me updated with what you have
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| kpmle2
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ngaybinhyen wrote:
1. Salicylate poisoning
- recommended in all symptomatic patients with regard of hypokalemia (common in salicylate poisoning)
- Diamox should NEVER be used as for acidemia and subsequent increased toxicity
2. Urinary alkalinization by PO NaHCO3 enhances the elimination of weak acids: salicylates, phenobarbital, chlorpropamide, chlorophenoxy herbicides, formic acid, and methotrexate
3. Pure uric acid stones
- dissolved with oral alkalinization, K citrate, Na bicarbonate --> urinary pH 6.5-7
4. Rhabdomyolysis: IV bicarb
5. hemoglobinuria (heatstroke)
Thanks buddy ngaybinhyen. 
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| ngaybinhyen
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| Eagle_303
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ngaybinhyen wrote:actually, urine acidification is not recommended any more as it harms more than it benefits the patients. Correct? Keep me updated with what you have
As you alkanize the urine with for poisoning of weak acids, you acify the urine for poisoning because of weak bases like amphetamine.
Just a guess .
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| sucralfate
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ngaybinhyen wrote:actually, urine acidification is not recommended any more as it harms more than it benefits the patients. Correct? Keep me updated with what you have
It was recommended for the renal elimination of amphetamines, PCP and strychnine. Now it's contraindicated because these drugs can produce rhabdomyolysis.
Urine acidification for UTIs is still controversial because it's based on weak evidence.
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