keepgoing
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A 56-year-old man who drinks a six-pack of beer a day, with higher alcoholic intake on weekends, holidays, and “special days,” presents to the internal medicine clinic. He has an abnormal plasma lipoprotein profile. It is known that erythrocyte fluidity is altered in liver disease. Which of the following would increase membrane fluidity in the hepatocytes of this
patient’s liver?
a. Restriction of rotational movement of proteins and lipids in the membrane
b. Transbilayer movement of phospholipids in the plasma membrane
c. Increased cholesterol/phospholipids ratio in the plasma membrane
d. Binding of integral membrane proteins with cytoskeletal elements
e. Binding of an antibody to a cell-surface receptor
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| loto
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C
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| keepgoing
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c wud dec membrane fluidity.
try again
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| GoodGirl
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b
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| SILVER
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B
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| keepgoing
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totally lost now.......
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| keepgoing
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answer E.
The patient in the scenario is suffering from cirrhosis in which there are alterations in plasma
lipoproteins. Binding of an antibody to a cell surface receptor results in lateral diffusion of protein in the lipid bilayer, resulting in increased membrane fluidity— patching and capping. Rotational and lateral movements of both proteins and lipids contribute to membrane fluidity.
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| GoodGirl
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me too Silver.
I have NO CLUE . Done with guessing.
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| GoodGirl
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Are the antibodies in vivo bind in alcoholic cirhosis? Am I missing something ? Must say, strange qs and more stranger answer. Too experimental for my taste.
Will think about ir for a minute.....
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GoodGirl wrote:me too Silver. I have NO CLUE . Done with guessing.
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| SILVER
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my question is how will the antibodies increase the fluidity and why are the Abs binding in the first place? basically what are we supposed to be learning from this question?
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| GoodGirl
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Hey, Silver, I'm sure KG meant it well by posting it here.... it happened to me, when I posted questions before, 1st I thought that question is good, than later realized it was a plain low yield topic...
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| keepgoing
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 no doubt starnge weird question..here is teh explanation.
The patient in the scenario is suffering from cirrhosis in which there are alterations in plasma
lipoproteins. Binding of an antibody to a cell surface receptor results in lateral diffusion of protein in the lipid bilayer, resulting in increased membrane fluidity— patching and capping. Rotational and lateral movements of both proteins and lipids contribute to membrane fluidity. Restriction reduces membrane fluidity (answer a). Phospholipids are capable of lateral diffusion,rapid rotation around their long axis, and flexion of their hydrocarbon (fatty
acyl) tails. They undergo transbilayer movement (answer b), known as “flipflop,”between bilayers in the endoplasmic reticulum; however, in general this does not occur in the plasma membrane. Other factors reduce membrane fluidity.An increase in the amount of cholesterol relative to phospholipid (answer c) has been shown by a variety of physicochemical techniques to decrease fluidity in both biological and artificial membranes by interacting
with the hydrophobic regions near the polar head groups and stiffening this region of the membrane. Association or binding of integral membrane proteins with cytoskeletal elements (answer d) on the interior of the cell and peripheral membrane proteins on the extracellular surface limit membrane mobility and fluidity.
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| SILVER
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GoodGirl wrote:
Hey, Silver, I'm sure KG meant it well by posting it here.... it happened to me, when I posted questions before, 1st I thought that question is good, than later realized it was a plain low yield topic...
oh no no! i'm not saying it's a bad question. i'm trying to understand what the concept is. high or low yield comes later..........just trying to see what this was all about.
in fact it's good to see someone posting step 1 questions after such a long time. i admit i've been slow too......was really into it a while back and then slowed down. even NNL used to post good ones, some other members too, i remember yours as well....anyways it's all good.
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| keepgoing
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guys sorry for such trouble but really scratching question did u get anything from explanation.
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| SILVER
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GoodGirl wrote:
Are the antibodies in vivo bind in alcoholic cirhosis? Am I missing something ? Must say, strange qs and more stranger answer. Too experimental for my taste.
Will think about ir for a minute.....
trying to digest it just like you buddy 
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keepgoing wrote:guys sorry for such trouble but really scratching question did u get anything from explanation.
i got what factors contribute to increased and decreased fluidity.
and beyond that i think i'm gonna leave it at that.  thanks keepgoing.
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| keepgoing
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yeah even i just grabed that what factors may affect fluidty of membrane thats it.rest dont sweat much..like GG said perhaps low yield i will be careful next time while posting question.
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| 1111doctor1111
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keepgoing or anyone else, what's the source of this q... cuz seriously it's not difficult, it's impossible!!!... i heard that UW qbank q's are more difficult than USMLE q's and 90% of those q's were doable and logical and somewhat related to what i studied...
anyway thanks for ure efforts keepgoing, it's sometimes good to have these difficult q's to get ure brain thinking, but i just wanted to make sure that this is not the standard of USMLE q's
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