Liferocks
Forum Senior
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Initially, screening tests for hepatitis C infection include enzyme immunoassay (EIA). If
the EIA is positive, recombinant immunoblot assay or polymerase chain reaction may be
used for confirmation of results. To minimize the chance that persons who are not infected
with hepatitis C test positive, which of the following is the most important?
(A) The EIA must have a high positive predictive value
(B) The EIA must have high sensitivity
(C) The EIA must have high specificity
(D) The recombinant immunoblot assay or polymerase chain reaction must have high
sensitivity
(E) The recombinant immunoblot assay or polymerase chain reaction must have high
specificity
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| ngaybinhyen
Forum Guru
Topics: 23
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E
My though is simply
- the screening test should have high sensitivity to reduce the chance of missing the disease
- the confirming test should have high specificity to not give a false positive Dx to the patient
==> when you talk about false positive, the answer would be focused on specificity of the confirming diagnostic test
Correct me if I'm wrong, guys
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| sucralfate
Forum Senior
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E
You must have a high PPV in the confirmatory test.
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| Liferocks
Forum Senior
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| zx_stien
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