shawn333
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what powers the Retrograde flow of vesicles in the axons .
A . Kinesins
B. Dyneins
any reasonable explannation . 8)
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| mash
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Dyneins
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| Bela
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Anterograde :arrow: Kinesins (+ :arrow: -)
Retrograde :arrow: Dyneins (- :arrow: +)
How do I remember these?
I am in the US which is on the left of the globe. And US represents cell somma. To go to Kina (China) which is on the right and represents the axon, I need Kinesins  I know it's stupid, but it helps!
Now, the biological explanation could be this:
In the cell body, u have Golgi apparatus, where all the proteins necessary for the well being of the axon are finished. Kinesins go from Golgi (-) pole :arrow: Axon (+) pole. The Dyneins do the opposite since they bring back the non-working proteins.
Kinesin: Golgi (cell body) :arrow: Cell Memb or axon
Dynein: Cell memb or axon :arrow: golgi or cell body.
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| Idiopathic
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Kinesins make me think of energy, and that makes me think of a little car that takes vesicles down the microtubule pathway, while dyneins are slow and methodical, ratcheting the car back up towards the cell body. sort of like an amusement park ride.
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| shawn333
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thanks , you are right . But i dont know whether this can be tested in anyway in step ?!
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| peekay
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shawn333
basic level molecular biology is fair game in step 1
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| mjl1717
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I think of it like this kinesin-energy. The energy to push or pull that synaptic vesicle (with Ach in it) via microtubules to the synaptic cleft (+)anterograde
Dynein has activity to move vesicles along microtubule in the opposite direction (-) retrograde (away from the cleft)
[They both have ATPase activity]
Idio-that was very picturesque
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| kalsam
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Thanks a lott....everybody..nice way to remember!!!
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| shawn333
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thanks
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