oddissy4u
Forum Guru
Topics: 107
Posts: 389
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whts r doc n contraindications in open angle and closure angle galucoma?
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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i can tell one ..epinephrine is C.I in close angle .
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| Bela
Forum Guru
Topics: 76
Posts: 412
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TCAs since they are antimuscarinics!
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La vita e bella!
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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u r right bela 
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| oddissy4u
Forum Guru
Topics: 107
Posts: 389
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B-1 agonists CI in closure angle?
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| santaclara
Forum Elite
Topics: 67
Posts: 299
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asmi what about PILOCARPINE in emegency treatment of both open as well as close angle glaucome.
ACETAZOLAMIDE ALSO
AND I THINK B-ADERENGIC BLOCKER(TIMOLOL).
IF WRONG CORRECT ME PLS.
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| bluestar
Forum Guru
Topics: 236
Posts: 724
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asmi, is it becuase epinephrine can increase outflow of aqueous humor and can actually worsen IOP that it can't be used in closed-angled glaucoma? what are the mechanisms of other medications that can't be applied on glaucoma?
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| drdk76
Forum Newbie
Topics: 2
Posts: 21
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open angle glaucoma--is due to decreased absorption of aq.humor which accumulates & IOP rises--hence aim would be to decrease formation of aq.humor--normally aq.humor formed by ciliary epithelium under adrenergic influence,also req HCO3 in the process--so carbonic anhydrase inhibitors(decreaseHCO3 availability) --acetazolamide:b-blockers(timolol) which block adrenergic activity are used in order to reduce aq humor formation. in addition apraclonidine--alpha 2 agonist( which decrease NE release prejunctionally) can also be used.this is the rationale behind drug therapy in open angle glaucoma
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| drdk76
Forum Newbie
Topics: 2
Posts: 21
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angle closure glaucoma is due to blockage of outflow at the level of canal of schlemm --the block is aggravated by mydriatics (anticholinergics--of course TCA which have M blocking effect) the block is partially releived by miotics- (cholinomimetics-pilocarpine). but iam a bit confused about how epinephrine acts to increase outflow-- is there something to do with receptors? there is only alpha 1 receptor in the radial muscle.... ? please explain...
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