DrAlex_76
Forum Guru
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A 68 yo woman has had fatigue for 3 months. She is on digoxin, thiazide, enalapril and naproxen for her CAD and arthritis. She also had amox for her recurrent bronchiti. Her BUN = 60, creatinin = 6. Which of the following caused her conditon ?
A. Amox
B. Digoxin
C.Enalapril
D.Thiazide
E.Naproxen
Giving explain , plz !
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| Eagle_303
Forum Guru
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It is Naproxin :
Explanation is as follows :
In three conditions Renal circulation is maitained by PGI2 and PGE2 :
- Shock
- Old age
- Congestive Cardiac failure
Consequently in all these three condition NSAIDS are like to compromise these Prostaglandin production leading to renal failure
best of luck
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| DrAlex_76
Forum Guru
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BUN /Cre >>> 20 times ? it still naproxen ?
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| Eagle_303
Forum Guru
Topics: 77
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Those drugs which compromise Renal ciculation i.e they cause Vasoconstriction are likely to produce picture of Pre-renal azotemia
- NSAIDS
- Costrast agent
- Cyclosporin
Just to Add
Indomethacin is the most dangerous in this matter
Aspirin is least dangerous
Rest of NSAIDS including Naproxin and Ibuprofen intermediate in causing this renal vasoconxtriction .
The only NSAIDS which is renal sparing is SUlindac
Edited by Eagle_303 on 09/20/08 - 03:34 PM
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| nightflight1945
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| nightflight1945
banned
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very high yield for the boards
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| GOGETA
Trying to get in PGY1
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I had that one correcttt
yuuuuuupi fpr me
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| ngaybinhyen
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Naproxen
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