maoudoody
Forum Guru
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why aldosterone will be decreased?.......wont doc converted by 11 hydroxylase to corticosterone which is converted to aldosterone by 18 alpha hydroxylase?
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| a3112
Forum Elite
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excess doca in zona fasciculata and reticulata will suppress the renin angio aldo system and thus zona glomerulosa will b suppressed.. so even when there is no deficiency in the pathway of aldo synthesis in zona glomerulosa, there will b a decreased aldo.. although doca is a weak MC, when in excess (as in this case due to adrenal hyperplasia)
so aldo wil decrease in all enzyme deficiencies..
i hope this helps..
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| a3112
Forum Elite
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http://www.prep4usmle.com/forum/thread/74980/
there was a good discussion on this topic in this thread.. have a look..
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| maoudoody
Forum Guru
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but doca will be converted to corticosterone then aldosterone
why to stop on the doca station when no def in 20 and 11 hydroxylase this was my question
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| a3112
Forum Elite
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zona fasc and reticulata have only till 11 hydroxylase.. they wont convert corticosterone to aldo.. actually they dont have those enzymes..
each zona has the enzymes required 4 the synth of its particular hormone..
so the aldo pathway ends at doca and corticosterone in ZF n ZR..
so inc doca ----> supp RAA ----> dec aldo..
i hope this helps a bit..
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| maoudoody
Forum Guru
Topics: 56
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OK GOT IT......2 ZONES WITH DOCA VS ONE ZONE WITH ALDO
THNX ALOT
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| a3112
Forum Elite
Topics: 7
Posts: 268
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yes now u got it right..
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