oddissy4u
Forum Guru
Topics: 107
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the difference in using carbidopa with levodopa as opposed to levodopa alone?
A. With carbidopa, there will be a reduced incidence of nausea and vomiting.
B. With carbidopa, there will be increased production of prolactin.
C. With carbidopa, there will be a lower incidence of dyskinesias.
D. Without carbidopa, there will be increased body temperature.
E. Without carbidopa, there will be an increased incidence of psychotic behavior
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| peekay
Forum Guru
Topics: 102
Posts: 588
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ANS=A
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| oddissy4u
Forum Guru
Topics: 107
Posts: 389
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correct but is C wrong?
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| mjl1717
Forum Hero
Topics: 959
Posts: 5,467
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peekay is correct again
1)carbidopa is dopamine decarboxylse inhibitor(doesnt cross BBB) USMLE wants you to know it decreases the metabolism of levadopa in the GI and peripheral tissues
2)It will lower the dose of levadopa 5 fold and decrease the severity of side effects of peripherally formed dopamine
3)Odd- The answer to your q is that adding carbidopa doesnt increase the efficacy of the combo more but it increases the availability of levadopa to the CNS.
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