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Kaplan Qbank USMLE



Author6 Posts
  #1

Citrate has a positive allosteric effect on which one of the following enzymes?

A. Pyruvate kinase
B. Acetyl CoA carboxylase
C. Phosphofructokinase
D. Fatty acid synthetase
E. Enolase

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The universe will yield to the will of the determined person.

  #2

fatty acid synthetase????

___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius

  #3

no that is not the answer....I choose c.....thought that citrate inhibited PFK...specifically PFK-1 in glycolysis.

___________________
The universe will yield to the will of the determined person.

  #4

Silly me....when I read the question...it says "positive allosteric effect"

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The universe will yield to the will of the determined person.

  #5

oh yeah,i forgot
ans is acetyl coa carboxylase.(rate limiting step of fa synthesis)

___________________
I hear and I forget. I see and I remember. I do and I understand.
--Confucius

  #6

that is right mash.... :shock: I forgot that too...

also note that in addition to allosteric activation by citrate...acetyl co a is also stimulated by insulin....so, this is how insulin promotes FA syn :P

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The universe will yield to the will of the determined person.







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